Literature searches on natural products and organic chemistry
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Post a project like this£10/hr(approx. $13/hr)
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Description
Experience Level: Entry
needs some help with literature searches on natural products and organic chemistry. You should be a scientist and preferably have some knowledge of one or more of the following: Botany, pharmacology, chemistry idealy to a degree or PhD level. E.g I may need a search in natutal fibres and their effects in medicines and need a litertaure search with references. It might look like this (copied from Pubmed):
Eur J Neurosci. 2016 Nov 17. doi: 10.1111/ejn.13481.
The perception of affective touch in Parkinson's disease and its relation to small fibre neuropathy.
Kass-Iliyya L1,2, Leung M2, Marshall A1,2,3, Trotter P3, Kobylecki C1,2, Walker S3, Gosal D1, Jeziorska M4, Malik RA4, McGlone F3, Silverdale MA1,2.
Author information
Abstract
Affective touch sensation is conducted by a sub-class of C-fibres in hairy skin known as C-Tactile (CT) afferents. CT afferents respond maximally to gentle skin stroking at velocities between 1 and 10 cm/s. Parkinson's disease (PD) is characterised by markedly reduced cutaneous C-fibres. It is not known if affective touch perception is influenced by C-fibre density and if affective touch is impaired in PD compared to healthy controls. We predicted that perceived pleasantness to gentle stroking in PD would correlate with C-afferent density and that affective touch perception would be impaired in PD compared to healthy controls. Twenty-four PD patients and 27 control subjects rated the pleasantness of brush stroking at an optimum CT stimulation velocity (3 cm/s) and two sub-optimal velocities (0.3 and 30 cm/s). PD patients underwent quantification of C-fibre density using skin biopsies and corneal confocal microscopy. All participants rated a stroking velocity of 3 cm/s as the most pleasant with significantly lower ratings for 0.3 and 30 cm/s. There was a significant positive correlation between C-fibre density and pleasantness ratings at 3 and 30 cm/s but not 0.3 cm/s. Mean pleasantness ratings were consistently higher in PD patients compared to control subjects across all three velocities. This study shows that perceived pleasantness to gentle touch correlates significantly with C-fibre density in PD. The higher perceived pleasantness in PD patients compared to controls suggests central sensitisation to peripheral inputs, which may have been enhanced by dopamine therapy.
© 2016 Federation of European Neuroscience Societies and John Wiley & Sons Ltd.
KEYWORDS:
C-tactile afferent; cornea; hedonic; pain; skin
PMID: 27859794 DOI: 10.1111/ejn.13481
[PubMed - as supplied by publisher]
Similar articles
Icon for Wiley
Select item 27819339
3.
Sci Rep. 2016 Nov 7;6:36473. doi: 10.1038/srep36473.
Recombinant spider silk from aqueous solutions via a bio-inspired microfluidic chip.
Peng Q1, Zhang Y1, Lu L1, Shao H1, Qin K2, Hu X1, Xia X2.
Author information
Abstract
Spiders achieve superior silk fibres by controlling the molecular assembly of silk proteins and the hierarchical structure of fibres. However, current wet-spinning process for recombinant spidroins oversimplifies the natural spinning process. Here, water-soluble recombinant spider dragline silk protein (with a low molecular weight of 47 kDa) was adopted to prepare aqueous spinning dope. Artificial spider silks were spun via microfluidic wet-spinning, using a continuous post-spin drawing process (WS-PSD). By mimicking the natural spinning apparatus, shearing and elongational sections were integrated in the microfluidic spinning chip to induce assembly, orientation of spidroins, and fibril structure formation. The additional post-spin drawing process following the wet-spinning section partially mimics the spinning process of natural spider silk and substantially contributes to the compact aggregation of microfibrils. Subsequent post-stretching further improves the hierarchical structure of the fibres, including the crystalline structure, orientation, and fibril melting. The tensile strength and elongation of post-treated fibres reached up to 510 MPa and 15%, respectively.
PMID: 27819339 PMCID: PMC5098227 DOI: 10.1038/srep36473
[PubMed - in process] Free PMC Article
Similar articles
Icon for Nature Publishing GroupIcon for PubMed Central
Select item 27806663
4.
[END]
I need help over the next 4 weeks - probably around 8 - 16 hour per week (or more if you are free). Preference is given to those in Asia (with excellent English) where the hourly rate is less, but if you are very good/experienced at literature searches (and therefore are faster) then western freelancers are encouraged to apply.
Eur J Neurosci. 2016 Nov 17. doi: 10.1111/ejn.13481.
The perception of affective touch in Parkinson's disease and its relation to small fibre neuropathy.
Kass-Iliyya L1,2, Leung M2, Marshall A1,2,3, Trotter P3, Kobylecki C1,2, Walker S3, Gosal D1, Jeziorska M4, Malik RA4, McGlone F3, Silverdale MA1,2.
Author information
Abstract
Affective touch sensation is conducted by a sub-class of C-fibres in hairy skin known as C-Tactile (CT) afferents. CT afferents respond maximally to gentle skin stroking at velocities between 1 and 10 cm/s. Parkinson's disease (PD) is characterised by markedly reduced cutaneous C-fibres. It is not known if affective touch perception is influenced by C-fibre density and if affective touch is impaired in PD compared to healthy controls. We predicted that perceived pleasantness to gentle stroking in PD would correlate with C-afferent density and that affective touch perception would be impaired in PD compared to healthy controls. Twenty-four PD patients and 27 control subjects rated the pleasantness of brush stroking at an optimum CT stimulation velocity (3 cm/s) and two sub-optimal velocities (0.3 and 30 cm/s). PD patients underwent quantification of C-fibre density using skin biopsies and corneal confocal microscopy. All participants rated a stroking velocity of 3 cm/s as the most pleasant with significantly lower ratings for 0.3 and 30 cm/s. There was a significant positive correlation between C-fibre density and pleasantness ratings at 3 and 30 cm/s but not 0.3 cm/s. Mean pleasantness ratings were consistently higher in PD patients compared to control subjects across all three velocities. This study shows that perceived pleasantness to gentle touch correlates significantly with C-fibre density in PD. The higher perceived pleasantness in PD patients compared to controls suggests central sensitisation to peripheral inputs, which may have been enhanced by dopamine therapy.
© 2016 Federation of European Neuroscience Societies and John Wiley & Sons Ltd.
KEYWORDS:
C-tactile afferent; cornea; hedonic; pain; skin
PMID: 27859794 DOI: 10.1111/ejn.13481
[PubMed - as supplied by publisher]
Similar articles
Icon for Wiley
Select item 27819339
3.
Sci Rep. 2016 Nov 7;6:36473. doi: 10.1038/srep36473.
Recombinant spider silk from aqueous solutions via a bio-inspired microfluidic chip.
Peng Q1, Zhang Y1, Lu L1, Shao H1, Qin K2, Hu X1, Xia X2.
Author information
Abstract
Spiders achieve superior silk fibres by controlling the molecular assembly of silk proteins and the hierarchical structure of fibres. However, current wet-spinning process for recombinant spidroins oversimplifies the natural spinning process. Here, water-soluble recombinant spider dragline silk protein (with a low molecular weight of 47 kDa) was adopted to prepare aqueous spinning dope. Artificial spider silks were spun via microfluidic wet-spinning, using a continuous post-spin drawing process (WS-PSD). By mimicking the natural spinning apparatus, shearing and elongational sections were integrated in the microfluidic spinning chip to induce assembly, orientation of spidroins, and fibril structure formation. The additional post-spin drawing process following the wet-spinning section partially mimics the spinning process of natural spider silk and substantially contributes to the compact aggregation of microfibrils. Subsequent post-stretching further improves the hierarchical structure of the fibres, including the crystalline structure, orientation, and fibril melting. The tensile strength and elongation of post-treated fibres reached up to 510 MPa and 15%, respectively.
PMID: 27819339 PMCID: PMC5098227 DOI: 10.1038/srep36473
[PubMed - in process] Free PMC Article
Similar articles
Icon for Nature Publishing GroupIcon for PubMed Central
Select item 27806663
4.
[END]
I need help over the next 4 weeks - probably around 8 - 16 hour per week (or more if you are free). Preference is given to those in Asia (with excellent English) where the hourly rate is less, but if you are very good/experienced at literature searches (and therefore are faster) then western freelancers are encouraged to apply.
Dr John W.
97% (18)Projects Completed
16
Freelancers worked with
12
Projects awarded
24%
Last project
27 May 2020
Brazil
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