
Show on a chemical formula the phosphorylation of ampa receptors
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Description
Experience Level: Expert
I have an example of how it needs to be done, what type of reaction
That is the text :
The ionotropic alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptor is densely distributed in the mammalian brain and is primarily involved in mediating fast excitatory synaptic transmission. Recent studies in both heterologous expression systems and cultured neurons have shown that the AMPA receptor can be phosphorylated on their subunits (GluR1, GluR2, and GluR4). All phosphorylation sites reside at serine, threonine, or tyrosine on the intracellular C-terminal domain. Several key protein kinases, such as protein kinase A, protein kinase C, Ca2+/calmodulin-dependent protein kinase II, and tyrosine kinases (Trks; receptor or nonreceptor family Trks) are involved in the site-specific regulation of the AMPA receptor phosphorylation. Other glutamate receptors (N-methyl-d-aspartate receptors and metabotropic glutamate receptors) also regulate AMPA receptors through a protein phosphorylation mechanism. Emerging evidence shows that as a rapid and short-term mechanism, the dynamic protein phosphorylation directly modulates the electrophysiological, morphological (externalization and internalization trafficking and clustering), and biochemical (synthesis and subunit composition) properties of the AMPA receptor, as well as protein-protein interactions between the AMPA receptor subunits and various intracellular interacting proteins. These modulations underlie the major molecular mechanisms that ultimately affect many forms of synaptic plasticity.
I would like to show on a formula that pkmz does phosphorylates ampa receptors.
If anyone can help with this please let me know.
The exact sentence that I would like to show on a formula is :
In particular, specific glutamate receptors called ampa-receptors, are activated, and the following neurochemicals are also released - dopamine, cortisol and noradrenaline.
In addition your ampa-receptors are phosphorylated by a chemical similar to PKM Zeta.
This PKM Zeta-like chemical has a profound impact on how we react and encode traumatic experiences.
That is the text :
The ionotropic alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptor is densely distributed in the mammalian brain and is primarily involved in mediating fast excitatory synaptic transmission. Recent studies in both heterologous expression systems and cultured neurons have shown that the AMPA receptor can be phosphorylated on their subunits (GluR1, GluR2, and GluR4). All phosphorylation sites reside at serine, threonine, or tyrosine on the intracellular C-terminal domain. Several key protein kinases, such as protein kinase A, protein kinase C, Ca2+/calmodulin-dependent protein kinase II, and tyrosine kinases (Trks; receptor or nonreceptor family Trks) are involved in the site-specific regulation of the AMPA receptor phosphorylation. Other glutamate receptors (N-methyl-d-aspartate receptors and metabotropic glutamate receptors) also regulate AMPA receptors through a protein phosphorylation mechanism. Emerging evidence shows that as a rapid and short-term mechanism, the dynamic protein phosphorylation directly modulates the electrophysiological, morphological (externalization and internalization trafficking and clustering), and biochemical (synthesis and subunit composition) properties of the AMPA receptor, as well as protein-protein interactions between the AMPA receptor subunits and various intracellular interacting proteins. These modulations underlie the major molecular mechanisms that ultimately affect many forms of synaptic plasticity.
I would like to show on a formula that pkmz does phosphorylates ampa receptors.
If anyone can help with this please let me know.
The exact sentence that I would like to show on a formula is :
In particular, specific glutamate receptors called ampa-receptors, are activated, and the following neurochemicals are also released - dopamine, cortisol and noradrenaline.
In addition your ampa-receptors are phosphorylated by a chemical similar to PKM Zeta.
This PKM Zeta-like chemical has a profound impact on how we react and encode traumatic experiences.
George A.
100% (5)Projects Completed
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Last project
12 Jan 2021
United Kingdom
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Hello George, do you need an illustration 3D or just the chemical formula? You can contact me.
George A.17 Mar 2017Just the chemical formula
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This is a project intended to?
(web, presentation, press article...? )George A.17 Mar 2017Is intented for a small presentation.just the chemical formula needed
Laurent L.17 Mar 2017poster maybe?
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